EXPERIMENTAL CANCER CHEMOTHRAPY RESEARCH LAB. Co., Ltd.

Achievement

Since 1975, a number of HTXs derived from cancer patients have been transplanted in nude mice of the same sex as the donor patient and established under an aseptic condition, and also some established HTXs were distributed from other institutes. Altogether 50 HTXs have been passaged so far in nude mice.

The biological characteristics of HTXs and given drug-sensitivity to their HTXs had been examined. We have investigated the biological parameters that are related to drug sensitivity.

It was found that the drug sensitivities between tumors' in donor patients and corresponding, established HTXs in nude mice were excellently correlative (papers: Japanese 34, English 22, others 2, General remarks, Interpretation 3).

We had taken over the surgical department duties from the former Department of Surgery Research Institute for Microbial Diseases, Osaka University, Japan, and had 144 contracts, conducted more than 800 experiments, including some of approved drugs and/or under judgment. Our HTX-transplanted nude mouse system has been estimated internationally as a highly-developed model. (Our Lab and name are listed in “ Who’s who”)

Representative publication

General remarks, Interpretation:

  • F. Fujita, M. Fujita, Human Xenograft Model. In: M. Nomura, I. Horii, T. Yoshida (eds), Manual for Non-Clinical Studies, L.I.C. Inc., Tokyo, 2001, pp449-463

Original article:

  • M. Fujita, F. Fujita, Y. Sakamoto, T. Sugimoto, K. Shimozuma, T. Taguchi, : Predictability of preclinical evaluaion of anticancer drugs by human gastrointestinal cancer-nude mouse panel. Jpn J Cancer Chemother, 18(9):1429-1437, July 1991.
  • F. Fujita, M. Fujita, T. Taguchi, K. Shimozuma, Y. Sakamoto, Y. Kimoto, and T. Hirai. :  Maltifactorial analysis of parameters influencing chemosensitivity of human cancer xenografts in nude mice.  Int. J. Cancer. 43:637-644, 1989.
  • Masako Koike, Fumiko Fujita, Kinuyo Komori et al. : Dependence of chemotherapy response on p53 mutation status in a panel of human cancer lines maintained in nude mice. Cancer Science, 95(6), 541-546, 2004.

Record of exam-contracts

<Company>

Some may be formerly names of company, because those are from old contract information.

Mitsubishi Pharma Corp.
12
UMN Pharma, Inc.
2
Ebara Corp.
2
Aneropharma Science Inc.
1
Eli Lilly Japan K.K.
8
Otsuka Pharma Co., Ltd.
16
Eisai Co., Ltd.
6
Bristol-Myers K.K.
2
Aventis Pharma Ltd.
3
Shionogi & Co., Ltd.
2
Ishihara Sangyo Kaisha Ltd.
5
Fuji Yakuhin Co., Ltd.
4
Nippon Shinyaku Co., Ltd.
6
Sankyo Co., Ltd.
9
Kyowa Hakko Kogyo Co., Ltd.
12
Mitsui Pharma Inc.
2
SmithKline Beecham Seiyaku K.K.
4
Yoshitomi Pharma Industries, Ltd.
8
Tanabe Seiyaku Co., Ltd.
11
Dainippon Pharma Co., Ltd.
2
Taisho Pharma Co., Ltd.
3
Banyu Pharma Co., Ltd.
3
Asahi Kasei Corp.
1
Hechst Marion Rousel Inc.
6
Ciba-Geigy Japan Ltd.
3
Teikoku Hormone MFG. Co., Ltd.
4
Nippon Roche K.K.
2
Daiichi Pharma Co., Ltd.
2
Mercian Corp.
1
Taiho Pharma Co., Ltd.
1
Kanefuchi Che. Co., Ltd.
1
Otsuka Pharma Factory Inc.
1
The Green Cross Corp.
1
Kashiyama Rikagakukenkyusho
1

University

Osaka University of Pharmaceutical Sciences
1
Osaka City University
1
Individual
Individual
1

Total 151 cases

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